Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-Aspartic Acid (DAA) is a naturally occurring amino acid that has been investigated for its potential to support or increase testosterone levels, particularly in men with low testosterone. The rationale for its use stems from early animal and some small-scale human studies suggesting that DAA may play a role in regulating the synthesis and release of hormones associated with the hypothalamic-pituitary-gonadal axis, potentially leading to increased testosterone production. A frequently cited 2009 study found that healthy men taking 3g of DAA daily for 12 days experienced a modest (~42%) increase in testosterone, but these effects were short-lived and not consistently reproducible. Subsequent, larger, and better-controlled studies have produced mixed or negative results. Research involving resistance-trained men, as well as studies of longer duration, generally failed to show significant or sustained increases in testosterone levels compared to placebo. A 2015 systematic review concluded that DAA supplementation does not reliably enhance testosterone in healthy men and may even decrease it at higher doses. The evidence base is limited by small sample sizes and short follow-up periods. In summary, while there is some scientific rationale for the use of DAA to support testosterone, the current body of evidence is weak and inconsistent, earning it a low evidence rating for this purpose. DAA is not traditionally used for this purpose, and there is little strong scientific validation for its efficacy in treating low testosterone.

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