Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) is sometimes included in supplements aimed at supporting testosterone levels, and there is some scientific rationale for its use, though evidence in humans is limited and not particularly robust. Vitamin B6 plays a role in several enzymatic reactions involved in amino acid metabolism and neurotransmitter synthesis. Some animal studies and in vitro experiments have suggested that vitamin B6 deficiency can impair the synthesis of androgens, including testosterone, possibly by affecting the hypothalamic-pituitary-gonadal (HPG) axis. For example, B6 deficiency in rats has been associated with reduced testosterone production and altered hormone levels.

In humans, a few studies have explored vitamin B6's effects on hormone balance, but direct evidence linking B6 supplementation to increased testosterone levels in healthy men is lacking. Most human data are indirect, such as studies on B6’s effect on prolactin, a hormone that can inversely affect testosterone. Some evidence suggests B6 may help maintain normal testosterone levels by supporting overall hormonal balance, particularly under stress or deficiency states, but there is no high-quality clinical trial demonstrating a significant testosterone-boosting effect in healthy individuals.

In summary, while there is some scientific basis—primarily from animal research and mechanistic understanding—for the inclusion of vitamin B6 in testosterone-support formulas, the direct evidence in humans is modest. Therefore, the overall strength of evidence is rated as low to moderate (2/5).

More about vitamin B6
More about Testosterone

Other ingredients that support Testosterone

Other body systems supported by vitamin B6

Products containing vitamin B6

Nature's Sunshine Love and Peas (Sugar Free Original Formula)
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas (Sugar Free) NEW!
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens Pouch
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal Chocolate
Nature's Sunshine Power Meal Vanilla
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave