The use of testicular tissue or extracts (often called "orchic extract") to support testosterone and male reproductive health has a historical basis in organotherapy, a practice from the late 19th and early 20th centuries. The theory was that consuming the organs of animals would support the corresponding organs in humans. However, scientific studies have shown that consuming testicle tissue does not directly increase testosterone levels in humans due to the breakdown of proteins and hormones during digestion.

Modern scientific validation is limited, but some animal studies suggest that certain nutrients found in testicular tissue (such as cholesterol, zinc, and proteins) are important for hormone synthesis. These are not unique to testicular tissue, however, and are available from many dietary sources. The direct ingestion of animal testicles does not appear to reliably raise testosterone levels in humans. Instead, medical science relies on exogenous testosterone (as in testosterone replacement therapy) or drugs that stimulate endogenous production for clinically significant effects.

In summary, while there is a minor scientific rationale for the nutritional content of testicular tissue, there is no robust evidence that eating testicle or its extracts meaningfully supports testosterone production in humans. Most claims are extrapolated from traditional practices or very limited animal data.