Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eurycomanone is a quassinoid compound found in the roots of Eurycoma longifolia, commonly known as Tongkat Ali. This plant has a long history of traditional use in Southeast Asia as a remedy for male sexual disorders and to improve vitality. Scientific interest has focused on its potential to support testosterone production and related physiological effects. Several in vitro and animal studies indicate that eurycomanone can stimulate testosterone synthesis, likely by increasing the release of luteinizing hormone and promoting the conversion of cholesterol to testosterone in Leydig cells. A handful of small human studies, often using Tongkat Ali extracts standardized to eurycomanone, report modest increases in total and free testosterone levels in men experiencing late-onset hypogonadism or stress-related reductions in testosterone. However, these studies tend to be limited by small sample sizes, short durations, and variability in extract standardization.

Overall, while there is preliminary scientific evidence suggesting that eurycomanone may support the testosterone body system, the quality and quantity of human clinical data are not yet robust. More large-scale, well-controlled trials are needed to firmly establish efficacy and safety. Thus, the use of eurycomanone is justified by both traditional use and emerging scientific evidence, but current scientific validation remains moderate.

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