Evidence supporting the use of: D-Aspartic Acid
For the body system: Testosterone

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-Aspartic Acid (DAA) is an amino acid that has garnered attention for its potential role in supporting testosterone production. The initial scientific interest was sparked by studies in animals and some small human trials suggesting that DAA supplementation could temporarily increase testosterone levels. For example, a 2009 study by Topo et al. reported that men taking 3,120 mg of DAA daily for 12 days experienced a 42% increase in testosterone levels. However, subsequent research has produced mixed results. Several studies, including randomized controlled trials in healthy, resistance-trained men, have found no significant increase in testosterone levels with DAA supplementation. Moreover, some research even suggests that long-term or high-dose DAA supplementation could potentially decrease testosterone or have no effect at all.

Overall, while there is a scientific rationale for DAA's use in supporting the testosterone body system—primarily based on its role in the hypothalamic-pituitary-gonadal axis and some early positive findings—the evidence is inconsistent and not robust. The effect appears to be modest, temporary, or limited to certain populations (such as infertile men), and is not reliably replicated in healthy, resistance-trained young men. Thus, while "scientific" is the correct category, the evidence supporting DAA’s use for boosting testosterone in the general population is weak (rating: 2/5).

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