Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aminobutyric acid generally refers to gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the central nervous system. GABA is believed to play a role in promoting relaxation and reducing neuronal excitability, which is why it is sometimes used in dietary supplements marketed for tension, anxiety, or stress. The scientific rationale for its use is based on the known physiological action of endogenous GABA in the brain: by binding to GABA receptors, it can decrease neural activity and produce calming effects.

However, the oral supplementation of GABA for tension is only weakly supported by scientific evidence. A significant limitation is that GABA taken orally has poor ability to cross the blood-brain barrier, meaning its central effects may be limited. Some small studies and pilot trials have reported subjective reductions in stress or tension after GABA supplementation, but these studies are often limited by small sample sizes, lack of rigorous controls, and potential conflicts of interest. Systematic reviews and meta-analyses generally conclude that while there is a plausible mechanism, robust clinical evidence is lacking.

Therefore, while the use of aminobutyric acid (GABA) for tension has some scientific rationale and preliminary support, the evidence base is weak (rated 2/5), and further well-designed clinical trials are necessary to establish its efficacy and safety for this indication.

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