Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proteolytic enzymes, also known as proteases, have been studied for their potential to support the treatment of tendonitis due to their anti-inflammatory and fibrinolytic properties. These enzymes, such as bromelain, trypsin, and serrapeptase, are thought to help reduce inflammation and edema by breaking down inflammatory mediators and protein debris at the site of injury. Some clinical studies, including small randomized controlled trials, have suggested that oral proteolytic enzyme supplements may reduce pain and swelling and improve mobility in soft tissue injuries, including tendonitis. However, the quality of evidence is generally low, with limitations such as small sample sizes, short study durations, and lack of standardized protocols. Systematic reviews have concluded that while there is some positive preliminary data, the evidence is insufficient to recommend proteolytic enzymes as a standard therapy for tendonitis. Theoretical mechanisms are plausible, but more robust, high-quality trials are needed to confirm efficacy and safety. As such, the scientific support for using proteolytic enzymes in tendonitis is weak to moderate at best, and these supplements should not replace conventional treatment but may be considered as adjuncts under medical supervision.

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