Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lactoperoxidase is an enzyme naturally present in saliva and milk, and it plays an important role in the oral cavity’s antimicrobial defense. Scientific research has shown that the lactoperoxidase system, in combination with its substrates (such as hydrogen peroxide and thiocyanate), produces hypothiocyanite ions, which have bacteriostatic and bactericidal properties. This system inhibits the growth of cariogenic (cavity-causing) bacteria such as Streptococcus mutans and Lactobacillus species, which are significant contributors to dental caries and periodontal disease. Clinical studies and in vitro experiments support the use of lactoperoxidase in oral hygiene products (e.g., toothpastes, mouth rinses) to reduce plaque accumulation, gingival inflammation, and to maintain oral microbial balance. While lactoperoxidase does not directly remineralize teeth or act as a physical barrier, its antimicrobial effects help protect the teeth by reducing bacterial load and subsequent acid production that can erode enamel. The European Food Safety Authority and other reviews have acknowledged the plausibility of these benefits, though most evidence comes from studies on formulated oral care products rather than the isolated enzyme. Therefore, there is strong scientific rationale and moderate-to-strong clinical evidence supporting the use of lactoperoxidase to support oral and dental health.

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