Herbal blends have a long history of use in traditional medicine systems to support the body's stress response, which is governed largely by the sympathetic nervous system. Traditional Chinese Medicine (TCM), Ayurveda, and Western herbalism have employed various combinations of herbs such as ashwagandha, rhodiola, ginseng, licorice, and others, often in proprietary blends, to help the body manage stress, increase resilience, and maintain energy. These blends are often referred to as "adaptogenic," a concept rooted in mid-20th-century Russian herbal research, though many of the herbs were in use long before this classification. The rationale for using herbal blends is based on the belief that certain plants can help balance or modulate the body's response to stressors, thereby indirectly supporting the sympathetic nervous system. However, evidence for the efficacy of specific proprietary blends is generally limited and is often extrapolated from studies on individual herbs. Clinical trials on multi-herb formulations are less common, and their results are difficult to generalize due to variable composition. Therefore, while there is a strong traditional basis for the use of herbal blends in supporting stress response (and by extension, sympathetic nervous system function), robust scientific validation is limited, and the strength of evidence is modest.