Ginkgo biloba is most widely known for its potential effects on cognitive function, but some research has investigated its influence on the autonomic nervous system, including the Sympathetic Nervous System (SNS). The justification for its use in supporting the SNS is primarily based on scientific studies, though the evidence is limited and not robust.

Several small studies have explored Ginkgo biloba’s impact on circulation, vascular tone, and heart rate variability—factors influenced by the SNS. For example, some research suggests Ginkgo may promote peripheral vasodilation and improve microcirculation, possibly by modulating sympathetic activity and nitric oxide pathways. Additionally, a few studies have indicated that Ginkgo biloba extract could reduce stress-induced increases in blood pressure and heart rate, suggesting a mild sympatholytic (SNS-modulating) effect.

However, these findings are not consistent, and many studies focus on cognitive or vascular outcomes rather than direct measures of SNS function. There is not enough high-quality, large-scale evidence to support a strong influence of Ginkgo biloba on the Sympathetic Nervous System in healthy individuals. Therefore, while there is some scientific rationale and preliminary evidence for its use, the overall evidence base is weak and does not justify strong claims.