Sage (Salvia officinalis) has been traditionally used to reduce excessive sweating (hyperhidrosis), and this use is supported by emerging scientific evidence. The main compounds in sage, such as thujone and rosmarinic acid, are thought to possess anticholinergic properties, which may inhibit the activity of sweat glands. Several small clinical trials have investigated sage’s efficacy in reducing perspiration. For example, a double-blind, placebo-controlled study published in Phytomedicine (2006) found that sage leaf extract significantly reduced sweating in women suffering from excessive perspiration during menopause compared to placebo. Another study, published in Advances in Therapy (2010), demonstrated that a sage tablet reduced the frequency and severity of hot flushes and night sweats in menopausal women. Laboratory studies suggest sage extracts can inhibit acetylcholine-induced sweating in vitro, supporting the clinical findings. While the exact mechanism is not fully elucidated, the collective evidence from historical use and clinical research suggests sage can be effective in supporting the sweat glands body system by reducing excessive sweating. However, most studies have focused on menopausal sweating, and larger, more rigorous trials are needed to confirm these benefits across broader populations.