Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tripeptides—short chains of three amino acids—are increasingly researched for their potential role in supporting wound healing, including recovery from surgery. The most commonly studied tripeptides in this context are collagen-derived, such as Gly-Pro-Hyp, which are produced during the digestion of collagen supplements. Several in vitro and small animal studies have shown that these tripeptides can stimulate fibroblast proliferation and enhance the synthesis of extracellular matrix components, which are important for tissue repair. Preliminary human studies suggest oral intake of collagen peptides (which contain tripeptides) may accelerate wound healing and promote skin regeneration after surgical or dermatological procedures. However, these studies are often small, lack robust controls, or are sponsored by supplement manufacturers, limiting the strength of the evidence.

There is also emerging but limited clinical data suggesting potential benefits in terms of reduced healing time, improved tissue strength, and decreased risk of wound dehiscence when collagen-derived peptides are used as adjuncts in postoperative care. Nevertheless, independent, large-scale, randomized controlled trials specifically investigating isolated tripeptides (rather than mixed peptides or whole protein hydrolysates) in surgical healing are lacking. Thus, while the use of tripeptides for surgical healing has a plausible scientific basis and some early, promising results, the overall evidence remains preliminary and not yet sufficient for strong clinical recommendations.

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