Platelet-derived growth factor (PDGF) is scientifically validated as a supportive agent in surgical healing, particularly in enhancing tissue repair and regeneration. PDGF is a naturally occurring protein that plays a crucial role in wound healing by stimulating the proliferation and recruitment of cells such as fibroblasts and smooth muscle cells to the site of injury. Its application in surgery has been explored primarily through recombinant PDGF products, such as becaplermin gel, which is FDA-approved for the treatment of diabetic foot ulcers.

Clinical studies have demonstrated that PDGF can accelerate the healing process in various surgical and wound care contexts, including bone regeneration (e.g., periodontal surgery, spinal fusions), soft tissue repair, and chronic ulcers. For example, randomized controlled trials have shown improved healing rates in patients receiving topical or locally delivered PDGF compared to placebo groups. Meta-analyses support its efficacy, especially in difficult-to-heal wounds.

While PDGF has a solid scientific basis for use in certain surgical and wound healing situations, the strength of evidence varies depending on the specific indication and delivery method. It is not a universal remedy for all surgical recovery but is a well-established adjunct in specific contexts, such as orthopedic, dental, and chronic wound management.