Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ornithine has some scientific support for use in promoting healing after surgery, particularly in the context of wound healing and recovery from trauma. Ornithine is a non-essential amino acid involved in the urea cycle, and it serves as a precursor for the synthesis of polyamines, which are important for cell proliferation and tissue repair. Several clinical studies, primarily in the form of oral or intravenous L-ornithine or its salt, ornithine alpha-ketoglutarate (OKG), have explored its effects in surgical or trauma patients. Research indicates that supplementation with ornithine or OKG may improve nitrogen balance, support protein synthesis, and enhance wound healing, especially in patients with severe trauma, burns, or those undergoing major surgery. A number of randomized controlled trials and meta-analyses (see: Déchelotte et al., 1991; Cynober, 2004) have reported improved outcomes in terms of reduced infection rates, shorter hospital stays, and enhanced healing, especially in malnourished or critically ill patients. However, results are not universally consistent, and most benefits are observed in specific subgroups with increased metabolic needs or impaired healing. Overall, while there is moderate scientific evidence for ornithine’s role in surgical recovery, it is not a standard therapy and is used mainly as an adjunct in specific clinical scenarios.

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