Evidence supporting the use of: Iron
For the health condition: Surgery (healing from)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Iron supplementation is scientifically validated as beneficial for patients recovering from surgery, particularly in cases where blood loss has occurred or when the patient's iron stores are low. Surgical procedures, especially major ones, often result in significant blood loss, which can deplete hemoglobin and iron stores, leading to postoperative anemia. Anemia after surgery is associated with delayed wound healing, increased risk of infection, prolonged hospital stays, and reduced functional recovery. Numerous clinical guidelines and randomized controlled trials support the use of iron (oral or intravenous) to correct or prevent anemia in surgical patients, especially those undergoing orthopedic, cardiac, or gastrointestinal surgeries. Intravenous iron is often preferred in the perioperative period for faster replenishment of iron stores and to avoid gastrointestinal side effects of oral iron. Early correction of iron deficiency has been shown to improve postoperative outcomes, enhance healing, and reduce the need for blood transfusions. The evidence is particularly strong in elective surgeries where preoperative screening and correction of iron deficiency are feasible. While iron is not a direct wound-healing agent, it is crucial for hemoglobin synthesis, oxygen transport, and cellular proliferation—all essential processes in tissue repair and recovery from surgery.

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