Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Histidine alpha-ketoglutarate (HAKG) is primarily used in the context of organ preservation, especially during cardiac surgery, rather than as a direct agent to support "healing" from surgery. The combination is a key component of certain cardioplegic solutions (e.g., Bretschneider's HTK solution) employed to protect the myocardium by inducing cardiac arrest and minimizing ischemia-reperfusion injury during procedures such as heart transplantation or open-heart surgery. Scientific evidence indicates that HAKG helps maintain intracellular pH, buffers hydrogen ions, and supports cell membrane stability. Histidine acts as a buffer, while alpha-ketoglutarate serves as an energy substrate that can be metabolized during reperfusion. Clinical studies and systematic reviews support the efficacy of HTK solutions containing HAKG in maintaining organ function and reducing perioperative injury. However, its use is not for general "healing" post-surgery, but rather for protecting tissues during the surgical event itself. Therefore, the rating reflects moderate evidence (3/5) for its specific role in intraoperative organ protection, not for general wound healing or postoperative recovery. The distinction is important: while HAKG's use is scientifically validated within its intended application, its direct impact on healing from surgery outside organ preservation is not established.

More about Histidine alpha-ketoglutarate
More about Surgery (healing from)

Other ingredients used for Surgery (healing from)

Other health conditions supported by Histidine alpha-ketoglutarate

Products containing Histidine alpha-ketoglutarate