Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Fibroblast growth factors (FGFs) are a family of signaling proteins that play a crucial role in wound healing and tissue repair, which are essential processes following surgery. The scientific rationale for their use is based on extensive preclinical and clinical research demonstrating that FGFs, particularly FGF-2 (basic FGF), stimulate the proliferation and migration of fibroblasts, endothelial cells, and keratinocytes. These activities accelerate granulation tissue formation, angiogenesis, and re-epithelialization—key steps in the healing of surgical wounds. Multiple animal studies show that topical or locally delivered FGF enhances wound closure and improves the quality of healing tissue.

Clinically, recombinant human FGF-2 has been approved in some countries (notably Japan and China) for the treatment of chronic skin ulcers and for accelerating healing after skin grafting and surgical procedures. Randomized controlled trials have demonstrated that FGF-2 can significantly reduce healing time and improve outcomes in surgical wound care compared to standard treatments. However, its use is not yet widespread globally, partly due to regulatory hurdles and the need for further large-scale studies to confirm efficacy and safety across diverse populations and surgical contexts. Nevertheless, the existing scientific evidence justifies the therapeutic use of FGFs in surgical wound healing, especially in cases where conventional therapies are inadequate.

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