Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Amino Acid Blends/Complexes are used to support healing from surgery based on significant scientific evidence. After surgery, the body enters a catabolic state, increasing the demand for amino acids to support tissue repair, immune function, and protein synthesis. Several clinical studies have demonstrated that supplementation with essential amino acids (EAAs) or specific blends (often including arginine, glutamine, and branched-chain amino acids) can improve outcomes such as wound healing, preservation of lean body mass, and reduction of postoperative complications.

For example, randomized controlled trials (RCTs) in patients undergoing abdominal, orthopedic, and cardiac surgeries have shown that perioperative supplementation with amino acids can decrease infection rates, enhance wound closure, and speed recovery. Arginine and glutamine, in particular, are considered "conditionally essential" during periods of stress and trauma, such as surgery, because their endogenous production may not meet increased metabolic demands.

Systematic reviews and meta-analyses support these findings, especially in malnourished or high-risk surgical patients. Clinical guidelines from organizations such as the European Society for Clinical Nutrition and Metabolism (ESPEN) recommend amino acid supplementation in specific surgical populations.

However, the benefit is most pronounced in patients at nutritional risk; routine supplementation in all surgical patients is less clearly supported. Overall, the use of amino acid blends in the context of surgical healing is grounded in robust scientific evidence, particularly for targeted, at-risk patient groups.

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