Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polypodium leucotomos is a tropical fern whose extract has been studied for its photoprotective and anti-inflammatory properties, particularly in the context of sunburn and UV-induced skin damage. Several clinical and preclinical studies have demonstrated that oral supplementation with Polypodium leucotomos extract can reduce erythema (skin redness) caused by ultraviolet (UV) radiation. The mechanism appears to involve the extract’s antioxidant activity, which helps to neutralize reactive oxygen species generated by UV exposure, as well as modulation of immune responses and reduction of DNA damage in skin cells.

Randomized controlled trials in humans have shown that individuals taking Polypodium leucotomos extract experience a delayed onset and decreased severity of sunburn after controlled UV exposure compared to placebo. Some studies also report reduced levels of UV-induced inflammation and less histological damage in the skin. While the majority of research supports the use of Polypodium leucotomos as an adjunct to topical sunscreens rather than a replacement, the evidence base is significant enough to justify its use as a supportive intervention for preventing or lessening sunburn.

However, the number and size of clinical trials remain limited, and most research has been conducted in small populations. Further large-scale, long-term studies are needed to fully establish efficacy and optimal dosing. Nonetheless, current scientific evidence provides a moderate level of support for its use in this context.

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