Evidence supporting the use of: Vitamin K
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin K is scientifically validated as essential for the structural system, particularly bone health. It acts as a cofactor for the enzyme gamma-glutamyl carboxylase, which is necessary for the carboxylation of osteocalcin—a protein critical for binding calcium in the bone matrix. Numerous studies have shown that adequate vitamin K intake is associated with improved bone mineral density and a reduced risk of fractures. Deficiency in vitamin K can lead to impaired bone mineralization, increasing the risk of osteoporosis and bone fractures, especially in older adults. Additionally, both vitamin K1 (phylloquinone) and K2 (menaquinone) have been investigated for their roles in bone health, with K2 showing particular promise in some clinical studies for reducing bone loss and fracture rates. Authoritative bodies such as the National Institutes of Health and the European Food Safety Authority recognize vitamin K's role in maintaining normal bone structure. While vitamin K’s most well-known function is in blood clotting, its role in supporting the structural integrity of bones is well established in the scientific literature. Thus, the use of vitamin K to support the structural system is strongly supported by scientific evidence.

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