Evidence supporting the use of: Hydroxyproline
For the body system: Structural System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hydroxyproline is a non-essential amino acid primarily found in collagen, the main structural protein in connective tissues such as skin, bone, cartilage, and tendons. Its role in the structural system, particularly in supporting connective tissue health, is scientifically validated. Hydroxyproline is critical for collagen stability; it enables the formation and maintenance of the triple-helix structure of collagen fibers, which imparts strength and resilience to tissues. Scientific studies have shown that levels of hydroxyproline in tissue or serum can serve as a biomarker for collagen content and turnover.

Supplementation with collagen peptides, which are rich in hydroxyproline, has been associated in some human and animal studies with improved skin elasticity, reduced wrinkles, and enhanced joint and bone health. However, it is unclear whether hydroxyproline itself, when administered separately, provides the same benefits as whole collagen or collagen peptides. Most clinical trials focus on collagen hydrolysates rather than isolated hydroxyproline. Still, the biochemical basis for hydroxyproline's importance in collagen synthesis is well-established.

Overall, the use of hydroxyproline to support the structural system is justified by its essential role in collagen structure and turnover, though the evidence for direct supplementation benefits is moderate and mostly extrapolated from studies on collagen itself.

More about hydroxyproline
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Other body systems supported by hydroxyproline

Joints
Skeletal System (Bones)
Skin
Structural System

Products containing hydroxyproline

We currently have no products on Caring Sunshine that contain this ingredient.