Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hyaluronic acid is a naturally occurring glycosaminoglycan found in connective tissues, skin, and synovial fluid. Its primary function in the structural system—specifically in joints—is to provide lubrication and cushioning. Scientific studies have demonstrated that hyaluronic acid is effective in supporting joint health, particularly in osteoarthritis. Intra-articular injections of hyaluronic acid are commonly used in clinical practice to alleviate pain and improve mobility in osteoarthritic joints, a procedure known as viscosupplementation. Meta-analyses and randomized controlled trials have shown modest benefits in pain reduction and functional improvement compared to placebo, though the clinical significance is sometimes debated among experts. Oral supplementation of hyaluronic acid has less robust supporting evidence, but some small studies report potential benefits for joint comfort and cartilage health.

While hyaluronic acid is not as well known for supporting other structural system components such as bones or tendons, its role in maintaining the extracellular matrix and tissue hydration contributes indirectly to structural integrity. However, most of the clinical evidence centers on its use for joint-related conditions rather than broad structural system support. Overall, the evidence is strongest for joint lubrication and osteoarthritis symptom relief, leading to a moderate rating for its use in supporting the structural system.

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Products containing hyaluronic acid

Nature's Sunshine Everflex with Hyaluronic Acid
Nature's Sunshine Marine Collagen
Nature's Sunshine Silver Shield BioGuard Hand & Body Cream
Nature's Sunshine Structural System (30 Day Program)