Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fibroblast growth factor (FGF) is a family of proteins involved in a variety of biological processes, including cell growth, tissue repair, and embryonic development. Within the context of the structural system—which encompasses bones, cartilage, tendons, and other connective tissues—FGFs play a crucial role in tissue regeneration and repair. Scientific studies have demonstrated that FGFs, especially FGF-2 (basic FGF), stimulate the proliferation and differentiation of osteoblasts and chondrocytes, which are essential for bone and cartilage formation, respectively. Furthermore, FGFs are involved in angiogenesis (the formation of new blood vessels), which supports the healing and remodeling of structural tissues.

Preclinical research and some clinical trials have explored the use of recombinant FGFs to enhance bone healing, treat bone defects, and support cartilage repair, particularly in orthopedic and dental contexts. However, the clinical evidence is still emerging, and most applications are experimental or adjunctive rather than standard practice. There is moderate evidence supporting the role of FGFs in tissue engineering and regenerative medicine for the structural system, but routine therapeutic use in humans is not yet fully established. Thus, while there is a scientific basis for using FGFs to support the structural system, the strength of the evidence is moderate and primarily based on laboratory and early clinical studies rather than widespread clinical adoption.

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