Evidence supporting the use of: Nitric Oxide
For the health condition: Strokes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nitric oxide (NO) has been investigated as a potential therapeutic agent in stroke due to its role as a vasodilator and signaling molecule in the nervous system. Scientific research shows that endogenous NO contributes to the regulation of cerebral blood flow and may provide neuroprotection during ischemic events. In preclinical studies, administration of NO donors or modulation of NO pathways has shown mixed results—some demonstrating improved cerebral perfusion and reduced infarct size, while others have reported potential neurotoxicity at high concentrations or under certain conditions. Clinical evidence is limited but includes small trials where inhaled nitric oxide was used in acute ischemic stroke patients, showing possible improvements in cerebral blood flow without significant side effects. However, large-scale randomized controlled trials are lacking, and systematic reviews highlight inconsistent efficacy and the need for further research. Therefore, while the use of nitric oxide in stroke management is supported by scientific rationale and early-phase studies, the overall quality and quantity of evidence remains low, and it is not widely adopted in clinical practice outside of research settings. As such, nitric oxide for stroke is considered an experimental intervention, not a standard of care.

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Products containing Nitric Oxide

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