Evidence supporting the use of: Nerve growth factor
For the health condition: Strokes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nerve Growth Factor (NGF) has been investigated as a potential therapeutic agent for the treatment of stroke due to its well-established role in neuronal survival, differentiation, and repair. Preclinical studies in animal models of ischemic stroke have demonstrated that administration of NGF can reduce neuronal damage, promote neurogenesis, and improve functional recovery. These beneficial effects are attributed to NGF’s ability to prevent apoptosis (programmed cell death) of neurons and to facilitate synaptic plasticity and regeneration of neural circuits damaged during stroke. In clinical settings, however, the evidence remains limited and preliminary. A few small pilot studies and early-phase clinical trials have explored the use of NGF, primarily via intranasal or intracerebral administration, in patients with acute ischemic stroke. Results from these studies suggest some potential for neurological improvement and enhanced recovery, but the sample sizes have been small and the studies often lack robust controls. Additionally, safety concerns, especially with systemic administration, have limited widespread clinical application. Currently, NGF is not approved as a standard therapy for stroke, and larger, well-controlled clinical trials are needed to establish efficacy and safety. Therefore, while there is a scientific rationale and some preliminary evidence supporting NGF’s use in stroke, the overall strength of evidence is low (rated 2/5), and routine clinical use is not justified at this time.

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