Evidence supporting the use of: DHA-conjugated phosphatidylserine
For the health condition: Strokes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA-conjugated phosphatidylserine (DHA-PS) has a scientific rationale for its use in the context of stroke, primarily based on preclinical studies. Phosphatidylserine (PS) is a phospholipid found in neuronal membranes, and docosahexaenoic acid (DHA) is an omega-3 fatty acid crucial for brain health. Animal studies have shown that DHA-PS supplementation may help protect neurons against ischemic injury (as occurs in stroke) by reducing oxidative stress, inhibiting apoptosis, and supporting membrane fluidity and repair. For example, research in rodent models of stroke has demonstrated that administration of DHA-PS can reduce infarct size and improve neurological outcomes compared to controls. The proposed mechanisms include enhancement of neurogenesis, modulation of inflammatory signaling, and promotion of synaptic plasticity. However, clinical evidence in humans is lacking; there are no large-scale randomized controlled trials confirming efficacy or safety for stroke patients. Most available data are limited to laboratory and animal studies. Therefore, while there is a scientific basis and promising preclinical results, the evidence level is modest (rated 2/5), and DHA-PS cannot be recommended as a stand-alone or primary treatment for stroke at this time. Further research, including well-designed clinical trials, is required to establish its therapeutic role in human stroke management.

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