Evidence supporting the use of: Vitamin B6 (pridoxal 5-phosphate)
For the health condition: Stress

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6, particularly in its active form pyridoxal 5'-phosphate (PLP), is sometimes used as a supplement to support stress or stress-related symptoms. There is some scientific rationale for this use, primarily because vitamin B6 acts as a cofactor in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play roles in mood regulation and stress response. Low levels of vitamin B6 have been associated in observational studies with depressive symptoms and increased psychological stress. Some clinical trials suggest that supplementation with B vitamins, including B6, may have modest effects on mood and stress, especially in individuals with suboptimal baseline levels. However, the evidence is mixed and not robust; meta-analyses and systematic reviews generally report limited or inconsistent benefits for vitamin B6 alone in reducing stress or improving mood in healthy adults. The majority of studies use B6 in combination with other B vitamins, making it difficult to isolate its specific effects. Overall, while there is a plausible biological mechanism and some preliminary evidence, the scientific support for using vitamin B6 (PLP) specifically to treat or support stress is limited, and its efficacy has not been conclusively demonstrated in high-quality, large-scale clinical trials.

More about Vitamin B6 (pridoxal 5-phosphate)
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Other ingredients used for Stress

5-Hydroxytryptophan (5-HTP)
7-Keto-DHEA
acetyl l-carnitine
alpha-pinene
arjun tree
ashwagandha
asparagus
astragalus
waterhyssop
benegut perilla (proprietary)
bergamot
bifidobacterium bifidum
bifidobacterium lactis
bifidobacterium longum
sesame
black tea
bonito peptide
bupleurum falcatum
California poppy
caterpillar mushroom
chaga mushroom
chamomile
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
GABA (gamma aminobutyric acid)
gardenia
gotu kola
green tea
guayusa
heartwood
hibiscus
hops
jujube
kava root
kudzu
l-ornithine
l-taurine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lactobacillus brevis
lactobacillus casei
lactobacillus helveticus
lactiplantibacillus plantarum
lavender
lentinula edodes mycelia
lion's mane
liquid liver fractions
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
Acetyl-L-Tyrosine
oat
passionflower
peppermint oil
perilla
phosphatidylserine
phospholipids
pine bark
polygala root
pregnenolone
pyrroloquinoline disodium salt
quail egg
relora® (proprietary)
rhodiola
rose oil
saffron
sceletium
black ginger
skullcap
spearmint leaf
spinach
valerian root
velvet bean
vitamin B12
vitamin B6
mulberry
whole adrenal glandular
zinc
sarsaparilla
suma
jiaogulan
catnip
cardamom
anise
fumaria parviflora
bee pollen
lingzhi
kanna
silk tree
oriental arborvitae
anemarrhena asphodeloides
St. John's Wort
yerba mate
noni
wood betony
biota seed
goji berry
cocoa
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ashitaba
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Arjuna
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Antler
Agastache
Agrimony
Apigenin
Antrodia camphorata
Arginine aspartate
Albizia
Anserina
Agmatine
Agarwood
Alpha lactalbumin
Algal protein
Betony
Baikal Skullcap
Black spruce
Baccosides
Bacopin
Baicalein
Basidiomycota
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Brahmi
Bacopa
Buddha's Hand
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banana
Bifidobacteria
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Centella triterpenes
Common Monkey Flower
Clary sage
Chinese Mountain Ant
Codonopsis
Coriander
Clerodendrum phlomidis
Chinese Fleeceflower
Chuchuhuasi
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Coca
Chocolate
Capitate Valerian
Corktree
Catuaba
C-Phycocyanin
cypress
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Calamus
Cherimoya
Convolvulus prostratus
Corydalis
Convolvulus Pluricaulis
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Canscora
Dismutase
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
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Devil's Club
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Eurycoma Longifolia
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Ficus religiosa
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Griffonia simplicifolia
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Gastrodin
jasmine
Lotus
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Mimosa
Orchid
Poppy
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Spikenard
yohimbine

Products containing Vitamin B6 (pridoxal 5-phosphate)

We currently have no products on Caring Sunshine that contain this ingredient.