Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Sceletium tortuosum, commonly known as Kanna, has a long history of traditional use in South Africa, where indigenous people have chewed or smoked the plant to help relieve stress, anxiety, and boost mood. In more recent years, scientific interest has grown, and several studies have begun to elucidate its potential mechanisms and effects.

Modern research suggests that Sceletium acts primarily as a serotonin reuptake inhibitor (SRI) and may also interact with other neurotransmitter systems, such as dopamine. Clinical studies, though limited in number and scale, have shown promising results. For example, a small randomized controlled trial (RCT) published in 2013 found that a standardized extract of Sceletium (Zembrin) reduced anxiety-related activity in the amygdala of healthy volunteers. Other pilot studies and animal research support its anxiolytic and stress-reducing properties, likely attributable to alkaloids such as mesembrine.

However, despite these positive indications, the body of evidence remains relatively modest. Most studies are small and short-term, with limited data on long-term safety or effectiveness in clinical populations. Regulatory authorities in some countries allow its use as a dietary supplement for mood and stress support, but larger, high-quality trials are still needed to fully establish its efficacy and safety profile.

In summary, while traditional use provides a basis, there is emerging scientific evidence supporting Sceletium’s role in stress management, justifying a moderate evidence score.

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