Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols are a broad class of naturally occurring compounds found in plants, including flavonoids, phenolic acids, and stilbenes. Their use in supporting stress is primarily justified by scientific research, although the strength of evidence is moderate and largely based on preclinical and observational studies rather than robust clinical trials. Polyphenols are known for their antioxidant and anti-inflammatory properties, which may help modulate the body’s stress response by reducing oxidative stress and inflammation—both of which can be elevated during psychological stress. Some studies have investigated specific polyphenols, such as those found in green tea (e.g., epigallocatechin gallate, EGCG) or cocoa (e.g., flavanols), showing potential benefits in lowering perceived stress levels, improving mood, or modulating cortisol responses. However, most of this evidence comes from animal models or small human studies, and the effects are often modest. Furthermore, "polyphenol (unspecified)" is a vague term, and the efficacy may vary widely depending on the specific type and source of polyphenol. At present, while polyphenols are not a primary or established treatment for stress, there is emerging scientific rationale for their supportive role, primarily through their general effects on brain and cardiovascular health. Large, well-controlled human trials are needed to confirm their efficacy for stress management.

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