Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin is primarily known as a hormone that regulates sleep-wake cycles, but its use in managing stress has some scientific basis, although the evidence is not robust. Melatonin has indirect effects on stress due to its role in improving sleep quality, which is often disrupted by stress. Several small studies and preclinical trials suggest that melatonin may reduce subjective feelings of stress and anxiety, likely by modulating circadian rhythms and supporting restful sleep. Melatonin also exhibits antioxidant and anti-inflammatory properties, which may contribute to protecting the body from the physiological impacts of chronic stress. Some animal studies have indicated that melatonin can dampen stress-induced increases in cortisol (the primary stress hormone), but human data are less consistent. Clinical trials specifically evaluating melatonin for stress reduction in humans are limited and often confounded by overlapping anxiety or sleep disorders. Most research focuses on melatonin’s benefits for insomnia or jet lag, with stress reduction considered a secondary effect. Meta-analyses and systematic reviews recognize a potential benefit, but emphasize the need for larger, well-controlled studies to establish efficacy and optimal dosing for stress management specifically. In summary, while there is some scientific rationale for melatonin’s use in stress—primarily via its sleep-promoting and possible anxiolytic effects—the strength and quantity of clinical evidence are modest. Melatonin should not replace established stress management techniques, but may be considered as an adjunct in those experiencing stress-related sleep disturbances.

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Nature's Sunshine Melatonin Extra