Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG) is a major polyphenol found in green tea, and its use for stress management is primarily supported by emerging scientific evidence, though the strength of evidence is currently modest. Preclinical studies have shown that EGCG can exert anxiolytic and stress-reducing effects, possibly by modulating neurotransmitter systems (such as GABA, dopamine, and serotonin) and reducing biomarkers of oxidative stress and inflammation in the brain. For example, animal studies have observed reduced corticosterone (a stress hormone) levels and decreased anxiety-like behaviors after EGCG administration. In vitro and animal model research also suggests that EGCG may protect neurons against stress-induced damage by enhancing antioxidant defenses. Human clinical data are limited but promising. A few small randomized controlled trials have indicated that green tea extracts (containing EGCG) may promote relaxation, improve mood, and reduce subjective feelings of stress, especially when consumed regularly over several weeks. One study found that participants who consumed a beverage high in EGCG reported lower stress levels and had improved heart rate variability, a marker of stress resilience. However, it is difficult to isolate the effects of EGCG from other tea components, and studies are often small and short-term. In summary, while there is some scientific support for EGCG’s role in stress reduction, particularly from animal and mechanistic studies, robust human clinical evidence is still lacking. Its use is thus justified more by emerging scientific interest than by traditional use or strong clinical validation.

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