Evidence supporting the use of: Eleutherococcus senticosus
For the health condition: Stress
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Eleutherococcus senticosus, commonly known as Siberian ginseng, has a long history of use in traditional medicine systems, particularly in Russia and East Asia, for supporting the body during periods of stress. In modern times, it is often classified as an "adaptogen," a term used for herbs that purportedly help the body adapt to physical and mental stress. Several clinical studies have investigated its efficacy for stress-related outcomes. While some small trials and animal studies suggest that Eleutherococcus senticosus may reduce subjective feelings of fatigue and improve certain cognitive and physiological responses to stress, the overall quality of evidence is limited by small sample sizes, methodological flaws, and inconsistent results.
A 2010 systematic review (Liao et al., 2010, Phytotherapy Research) concluded that while there is some evidence suggesting Eleutherococcus may have anti-fatigue and stress-modulating effects, robust, high-quality clinical evidence is lacking. The purported mechanisms involve modulation of the hypothalamic-pituitary-adrenal (HPA) axis and antioxidant activity, but these are primarily demonstrated in preclinical models. Consequently, its use for stress is supported by both tradition and some scientific studies, but the scientific validation remains preliminary and not definitive.
Overall, the evidence supporting Eleutherococcus senticosus for stress is modest, warranting an evidence rating of 2 out of 5.
Other ingredients used for Stress
5-Hydroxytryptophan (5-HTP)7-Keto-DHEA
acetyl l-carnitine
alpha-pinene
arjun tree
ashwagandha
asparagus
astragalus
waterhyssop
benegut perilla (proprietary)
bergamot
bifidobacterium bifidum
bifidobacterium lactis
bifidobacterium longum
sesame
black tea
bonito peptide
bupleurum falcatum
California poppy
caterpillar mushroom
chaga mushroom
chamomile
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
GABA (gamma aminobutyric acid)
gardenia
gotu kola
green tea
guayusa
heartwood
hibiscus
hops
jujube
kava root
kudzu
l-ornithine
l-taurine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lactobacillus brevis
lactobacillus casei
lactobacillus helveticus
lactiplantibacillus plantarum
lavender
lentinula edodes mycelia
lion's mane
liquid liver fractions
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
Acetyl-L-Tyrosine
oat
passionflower
peppermint oil
perilla
phosphatidylserine
phospholipids
pine bark
polygala root
pregnenolone
pyrroloquinoline disodium salt
quail egg
relora® (proprietary)
rhodiola
rose oil
saffron
sceletium
black ginger
skullcap
spearmint leaf
spinach
valerian root
velvet bean
vitamin B12
vitamin B6
mulberry
whole adrenal glandular
zinc
sarsaparilla
suma
jiaogulan
catnip
cardamom
anise
fumaria parviflora
bee pollen
lingzhi
kanna
silk tree
oriental arborvitae
anemarrhena asphodeloides
St. John's Wort
yerba mate
noni
wood betony
biota seed
goji berry
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
7,8-Dihydroxyflavone
Aralia
Arjuna
akebia
Antler
Agastache
Agrimony
Apigenin
Antrodia camphorata
Arginine aspartate
Albizia
Anserina
Agmatine
Agarwood
Alpha lactalbumin
Algal protein
Betony
Baikal Skullcap
Black spruce
Baccosides
Bacopin
Baicalein
Basidiomycota
Banyan
Brahmi
Bacopa
Buddha's Hand
Borage
banana
Bifidobacteria
Bupleurum
bacoside
Baicalin
Bird's nest
Centella triterpenes
Common Monkey Flower
Clary sage
Chinese Mountain Ant
Codonopsis
Coriander
Clerodendrum phlomidis
Chinese Fleeceflower
Chuchuhuasi
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Coca
Chocolate
Capitate Valerian
Corktree
Catuaba
C-Phycocyanin
cypress
Cowslip
Calamus
Cherimoya
Convolvulus prostratus
Corydalis
Convolvulus Pluricaulis
Celastrus
Canscora
Dismutase
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dibenzo-alpha pyrones
Devil's Club
Date
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Eplotab
Erythrina
Emblicanin
Eurycoma Longifolia
Fo-Ti
Fragrant Rosewood
Ficus religiosa
Fish
Frankincense
Flavones
Goldthread
Gelsemium
Ginsenosides
Griffonia simplicifolia
gum
Galactooligosaccharides
Glycine
Gastrodin
jasmine
Lotus
Mistletoe
Mimosa
Orchid
Poppy
Pistachio
Rose
Spikenard
yohimbine
Other health conditions supported by Eleutherococcus senticosus
Adrenal FatigueAthletic and Exercise Aids
Concentration (poor)
Convalescence
Depression
Diabetes
Energy (lack of)
Fatigue
Hypertension
Memory and Brain Function
Stress
