Evidence supporting the use of: Dodeca-2E, 4E-Dienoic Acid Isobutylamide
For the health condition: Stress

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Dodeca-2E,4E-dienoic acid isobutylamide is one of the principal alkamides found in Echinacea species, particularly Echinacea angustifolia and Echinacea purpurea. Echinacea has been traditionally used by Native American tribes and later by European settlers, mainly for immune support, wound healing, and as a remedy for colds and infections. There is some historical mention of Echinacea being used as a "tonic" or "adaptogen," which in folk medicine implies a broad utility for supporting the body under stress or illness. However, these traditional uses typically referred to general well-being or recovery from illness, rather than stress in the modern psychological or physiological sense.

Modern scientific studies on dodeca-2E,4E-dienoic acid isobutylamide have focused primarily on its immunomodulatory, anti-inflammatory, and analgesic activities. There is limited and indirect scientific evidence suggesting Echinacea extracts (which contain this alkamide) may help the body adapt to stress, possibly by modulating the hypothalamic-pituitary-adrenal (HPA) axis or affecting cytokine production, but these effects have not been robustly demonstrated in clinical trials specifically addressing psychological stress or stress-related disorders. Therefore, the use of this compound for stress is based mainly on traditional uses and extrapolation from related effects, rather than direct scientific validation.

More about Dodeca-2E, 4E-Dienoic Acid Isobutylamide
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Other ingredients used for Stress

5-Hydroxytryptophan (5-HTP)
7-Keto-DHEA
acetyl l-carnitine
alpha-pinene
arjun tree
ashwagandha
asparagus
astragalus
waterhyssop
benegut perilla (proprietary)
bergamot
bifidobacterium bifidum
bifidobacterium lactis
bifidobacterium longum
sesame
black tea
bonito peptide
bupleurum falcatum
California poppy
caterpillar mushroom
chaga mushroom
chamomile
cordyceps
curcumin
damiana
DHA (docosahexaeonic acid)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
GABA (gamma aminobutyric acid)
gardenia
gotu kola
green tea
guayusa
heartwood
hibiscus
hops
jujube
kava root
kudzu
l-ornithine
l-taurine
l-theanine
l-tryptophan
l-tyrosine
lactium casein decapeptide
lactobacillus brevis
lactobacillus casei
lactobacillus helveticus
lactiplantibacillus plantarum
lavender
lentinula edodes mycelia
lion's mane
liquid liver fractions
maca
magnesium
magnolia
matcha
melatonin
mint
motherwort
muira puama
Acetyl-L-Tyrosine
oat
passionflower
peppermint oil
perilla
phosphatidylserine
phospholipids
pine bark
polygala root
pregnenolone
pyrroloquinoline disodium salt
quail egg
relora® (proprietary)
rhodiola
rose oil
saffron
sceletium
black ginger
skullcap
spearmint leaf
spinach
valerian root
velvet bean
vitamin B12
vitamin B6
mulberry
whole adrenal glandular
zinc
sarsaparilla
suma
jiaogulan
catnip
cardamom
anise
fumaria parviflora
bee pollen
lingzhi
kanna
silk tree
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yerba mate
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wood betony
biota seed
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ashitaba
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Agastache
Agrimony
Apigenin
Antrodia camphorata
Arginine aspartate
Albizia
Anserina
Agmatine
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Alpha lactalbumin
Algal protein
Betony
Baikal Skullcap
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Baccosides
Bacopin
Baicalein
Basidiomycota
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Bacopa
Buddha's Hand
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banana
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Centella triterpenes
Common Monkey Flower
Clary sage
Chinese Mountain Ant
Codonopsis
Coriander
Clerodendrum phlomidis
Chinese Fleeceflower
Chuchuhuasi
Cymbopogon Martini
Calea zacatechichi
Centella asiatica
Coca
Chocolate
Capitate Valerian
Corktree
Catuaba
C-Phycocyanin
cypress
Cowslip
Calamus
Cherimoya
Convolvulus prostratus
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Canscora
Dismutase
Dodeca-2E, 4E-Dienoic Acid Isobutylamide
Dibenzo-alpha pyrones
Devil's Club
Date
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
Eplotab
Erythrina
Emblicanin
Eurycoma Longifolia
Fo-Ti
Fragrant Rosewood
Ficus religiosa
Fish
Frankincense
Flavones
Goldthread
Gelsemium
Ginsenosides
Griffonia simplicifolia
gum
Galactooligosaccharides
Glycine
Gastrodin
jasmine
Lotus
Mistletoe
Mimosa
Orchid
Poppy
Pistachio
Rose
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yohimbine

Products containing Dodeca-2E, 4E-Dienoic Acid Isobutylamide

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