Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid) is an omega-3 fatty acid most commonly associated with brain health, cognitive function, and development. Its use to support or treat stress is based on emerging scientific interest, though robust clinical evidence is limited. Several observational and interventional studies have examined the relationship between omega-3 fatty acid intake and stress-related outcomes, such as perceived stress, anxiety, and mood disorders. Some research suggests that omega-3 supplementation—including DHA—may help modulate the body's response to stress by influencing neuroinflammation, neurotransmitter function, and neuronal membrane fluidity. For example, a few small clinical trials have reported that omega-3 supplementation can reduce perceived stress or anxiety scores in certain populations, such as medical students or individuals under chronic stress. However, these effects are often modest, and studies frequently use a combination of EPA and DHA rather than DHA alone, making it difficult to isolate DHA’s specific impact. Systematic reviews and meta-analyses generally conclude that while there may be a potential benefit, the quality and consistency of evidence are not strong. Therefore, the use of DHA for stress is scientifically plausible but not definitively validated, and more large-scale, well-controlled studies are needed. Its use is not strongly rooted in traditional medicine for this purpose.

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Products containing DHA (docosahexaenoic acid)

Nature's Sunshine Circulatory System
Nature's Sunshine Krill Oil (With Vitamin K2)
Nature's Sunshine Super Trio