Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cordyceps is a genus of medicinal fungi that has been used in traditional Chinese medicine for centuries, particularly as a tonic to increase vitality and resistance to fatigue. Its use for stress, however, is primarily supported by emerging scientific evidence, rather than long-standing traditional application specifically for stress. Preclinical studies have shown that Cordyceps may influence the hypothalamic-pituitary-adrenal (HPA) axis, which plays a central role in the body's response to stress. Animal studies suggest that extracts of Cordyceps can modulate cortisol levels and improve behavioral outcomes in stress-induced models, potentially by exerting adaptogenic effects.

Human clinical evidence remains limited but promising. Some small-scale clinical trials and pilot studies have suggested improvements in subjective feelings of fatigue, anxiety, and overall well-being after Cordyceps supplementation, though these findings often stem from studies focused on energy, endurance, or mood rather than stress per se. Proposed mechanisms include antioxidant effects, modulation of inflammatory pathways, and support of mitochondrial function.

Overall, while there is a growing body of preclinical data and some early human research suggesting Cordyceps may help the body adapt to stress, the evidence is not yet robust or specific enough to rate higher. More large-scale, well-designed clinical trials are needed to confirm its efficacy and clarify its role in stress management.

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