Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Centella triterpenes, derived from the plant Centella asiatica (also known as Gotu Kola), have a history of use in traditional medicine systems, particularly in Ayurveda and Traditional Chinese Medicine, for supporting mental well-being and alleviating stress. The herb has been traditionally used as a tonic to improve cognition, reduce anxiety, and promote calmness. However, the use of Centella triterpenes specifically for stress is primarily rooted in these historical practices rather than robust scientific validation.

Some preliminary scientific studies, mostly involving animal models or small-scale human trials, suggest that extracts of Centella asiatica may exert anxiolytic (anxiety-reducing) effects, potentially by modulating neurotransmitter systems such as GABA. For example, small clinical studies have shown modest reductions in self-reported anxiety and stress markers following supplementation with Centella extracts. However, these studies often lack rigorous methodology, have small sample sizes, or use whole plant extracts rather than isolated triterpenes, making it difficult to draw definitive conclusions about efficacy and mechanism of action. Larger, well-designed human trials are lacking.

In summary, the use of Centella triterpenes for stress is justified more by traditional use than by strong scientific evidence; while some early research is promising, the evidence remains preliminary and insufficient for strong clinical recommendations.

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