Caterpillar mushroom, also known as Cordyceps sinensis, has a long history of use in traditional Chinese and Tibetan medicine. Practitioners have prized it for its purported ability to improve vitality, stamina, and resilience to physical and mental stress. Historical texts and folk practices often recommend Cordyceps for enhancing energy and overall well-being, which is indirectly linked to stress adaptation. The traditional rationale is based on the mushroom's perceived capacity to restore balance ("qi") and support the body's natural defenses against fatigue and exhaustion.

Scientific studies examining Cordyceps for stress are limited and mostly preclinical. Some animal research suggests that Cordyceps extracts might help modulate the hypothalamic-pituitary-adrenal (HPA) axis, which plays a central role in stress response. These studies indicate potential anti-fatigue and adaptogenic properties, but robust clinical trials in humans specifically addressing psychological stress are lacking. Therefore, while the traditional use of Cordyceps for stress and vitality is well documented, contemporary evidence supporting its effectiveness for stress reduction in humans remains preliminary.

In summary, Cordyceps’ use for stress is primarily rooted in traditional medicine, with limited but growing scientific exploration. Anyone considering Cordyceps for stress should consult a healthcare provider, as the clinical evidence is not yet strong or conclusive.