Synopsis

Source of validity: Scientific
Rating (out of 5): 2

C-Phycocyanin, a pigment-protein complex derived from Spirulina (Arthrospira platensis), has been the subject of increasing scientific interest due to its antioxidant and anti-inflammatory properties. Some recent preclinical studies suggest that C-Phycocyanin may help in mitigating stress-induced damage, primarily by reducing oxidative stress and modulating neuroinflammatory pathways. Animal studies have shown that supplementation with C-Phycocyanin can decrease levels of stress markers such as corticosterone, and may improve behavioral outcomes in models of chronic stress. The mechanism is thought to involve the scavenging of reactive oxygen species (ROS) and the regulation of signaling pathways associated with inflammation and neuronal health. However, human studies directly assessing the impact of C-Phycocyanin on psychological or physiological stress are limited. Most available evidence comes from in vitro or animal models, and there is a lack of large, well-controlled clinical trials in humans to confirm efficacy for stress support or treatment. While the preliminary results are promising and suggest a role for C-Phycocyanin in supporting resilience to stress through its antioxidant effects, the current level of evidence is still considered low to moderate (rated 2/5). More robust human research is needed before definitive claims can be made about its effectiveness for stress management.

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