Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bifidobacterium longum is a probiotic bacterium that has attracted scientific interest for its potential effects on stress and mood regulation. Several preclinical and clinical studies have investigated its role as a psychobiotic—a probiotic that positively influences the gut-brain axis. The most notable research includes randomized controlled trials in which supplementation with B. longum (often the 1714 or 35624 strains) was associated with reduced stress markers and improved psychological wellbeing in healthy adults and individuals with irritable bowel syndrome (IBS). For example, a 2017 study published in "Translational Psychiatry" demonstrated that B. longum 1714 reduced perceived stress and improved memory performance in healthy volunteers. Other studies have shown reductions in cortisol levels and improvements in self-reported mood after supplementation. Mechanistically, B. longum is believed to modulate the hypothalamic-pituitary-adrenal (HPA) axis, reduce inflammation, and influence neurotransmitter production, all of which can play a role in stress responses. However, while the evidence is promising, it is important to note that the number of high-quality human trials remains relatively limited and often involves specific probiotic strains and short-term interventions. Further large-scale, long-term studies are needed to establish efficacy and optimal dosing. Overall, the current body of evidence suggests a moderate level of scientific support for the use of B. longum in stress reduction, warranting a rating of 3 out of 5.

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