Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin is a natural flavonoid found in many plants, most notably in chamomile. Its use for stress is primarily grounded in scientific research, though evidence is still in early stages and mainly preclinical. Apigenin has been shown to possess anxiolytic (anxiety-reducing) effects in animal studies, likely through modulation of the GABA_A receptors, which are also targeted by common anti-anxiety medications like benzodiazepines. Several rodent studies demonstrate that apigenin can reduce anxiety-like behaviors and promote sedation without significant side effects or dependence potential. These properties suggest a potential role in stress management, since chronic stress and anxiety often overlap both symptomatically and neurobiologically. However, high-quality human clinical trials are limited. Some small studies with chamomile extracts (which contain apigenin) have reported reduced anxiety symptoms in humans, but it is unclear if apigenin alone is responsible for these effects. Thus, while there is plausible biological and preclinical evidence to support its use for stress and anxiety, clinical validation in humans is not robust. In summary, apigenin shows promise as a stress-reducing agent based on scientific rationale and animal data, but definitive human evidence is lacking. Its use is better characterized as experimental rather than established.

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