Algal protein, derived from sources such as spirulina and chlorella, has been investigated for potential benefits in managing stress, though the scientific evidence remains limited and preliminary. A few small-scale clinical studies and animal models suggest that certain algae, particularly spirulina, may have adaptogenic and antioxidant properties that could indirectly support the body's resilience to stress. For example, spirulina contains high levels of phycocyanin, vitamins, and minerals, which may help modulate oxidative stress and inflammation—two physiological processes linked to chronic psychological stress.

In some studies, supplementation with spirulina has been associated with improvements in mood and reductions in anxiety, possibly due to its content of tryptophan, a precursor to serotonin. However, these studies tend to be of low methodological quality, with small sample sizes and limited duration. Systematic reviews and meta-analyses do not yet provide strong or consistent evidence supporting the use of algal protein specifically for stress reduction in humans.

There are no significant records of traditional use of algal protein specifically for stress in historical medical systems. The rationale for its use is largely based on its nutrient profile and findings from experimental research rather than robust clinical trials or longstanding traditional practices. Therefore, while there is some scientific rationale and early evidence, the overall support is weak, and more high-quality studies are needed.