Echinacea pallida has a longstanding history of use in traditional herbal medicine, particularly among Native American tribes and later in 19th- and early 20th-century North American herbalism. It was used for a variety of infections and inflammatory conditions, including sore throats and general upper respiratory tract issues. These traditional uses have led to its inclusion in modern herbal remedies marketed for throat infections such as Strep Throat, though most commercial Echinacea products use either Echinacea purpurea or Echinacea angustifolia.

However, scientific evidence supporting the use of Echinacea pallida specifically for Strep Throat is minimal. A few studies have examined Echinacea species for their general immunomodulatory and mild antimicrobial effects, but there is little to no direct clinical evidence that E. pallida can treat or shorten the course of Streptococcus pyogenes (the bacteria responsible for Strep Throat) infections. Most evidence is either anecdotal, based on in vitro studies, or extrapolated from studies on other Echinacea species, which themselves show mixed results when it comes to efficacy for respiratory infections.

In summary, the use of Echinacea pallida for Strep Throat is justified primarily by traditional use rather than robust scientific validation, and it should not be considered a substitute for antibiotics in confirmed cases of Strep Throat.