Evidence supporting the use of: Goldenseal
For the health condition: Staph Infections

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of use in traditional herbal medicine, especially among Native American tribes and early European settlers in North America. Traditionally, goldenseal root was used topically for skin infections and wounds, and internally for various infections, including those involving the respiratory and digestive tracts. The rationale for its use against staph (Staphylococcus) infections stems from its purported antimicrobial properties, attributed mainly to the alkaloids berberine, hydrastine, and canadine present in the plant.

Although in vitro studies have shown that berberine—a major constituent of goldenseal—can inhibit the growth of certain bacteria, including some Staphylococcus aureus strains, the concentrations required are often much higher than those achieved with traditional preparations or typical oral doses. Moreover, human clinical trials evaluating goldenseal for the treatment or prevention of staph infections are lacking. The majority of available evidence comes from laboratory research, animal studies, or anecdotal reports, rather than rigorous clinical trials.

In summary, goldenseal's use for staph infections is primarily supported by traditional use and limited laboratory data, rather than robust scientific validation. The current evidence for its effectiveness in treating staph infections in humans is weak and insufficient to support its clinical use for this specific condition.

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