Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mucopolysaccharides, also referred to as glycosaminoglycans (GAGs), are long chains of sugar molecules found in the body, especially in connective tissues. Topical formulations containing mucopolysaccharide polysulfate (MPS) are marketed in some countries for the treatment of soft tissue injuries like sprains and bruises. The proposed mechanism of action is anti-inflammatory and antithrombotic effects, potentially enhancing tissue repair and reducing edema at the site of injury. Several small clinical studies and reviews—primarily from Europe—have evaluated the efficacy of topical mucopolysaccharide polysulfate for sprains and similar soft tissue injuries. These studies suggest that MPS may reduce pain, swelling, and recovery time compared to placebo, but the effects are generally modest. The evidence is limited by small sample sizes, short study durations, and potential biases in study design. Notably, guidelines in English-speaking countries do not routinely recommend mucopolysaccharide for sprains, and its use is much less common outside certain European regions. In summary, there is some scientific evidence, albeit weak and not universally accepted, that mucopolysaccharide polysulfate may offer symptomatic relief in sprains when used topically. The quality of evidence is moderate to low, and further high-quality, large-scale trials are needed to establish its efficacy and safety for this indication.

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