Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Harpagosides are iridoid glycosides found in the plant Harpagophytum procumbens, commonly known as devil’s claw. There is some scientific evidence supporting the use of harpagosides for musculoskeletal pain, including that associated with sprains. Several clinical and preclinical studies have demonstrated that extracts standardized to harpagosides exhibit anti-inflammatory and analgesic properties, likely through inhibition of pro-inflammatory mediators such as COX-2 and TNF-α. However, most of the clinical trials have focused on chronic conditions like osteoarthritis and low back pain rather than acute injuries such as sprains. Some in vitro and animal studies suggest that harpagosides can reduce swelling, pain, and inflammatory cytokines, which may be relevant to the healing of sprains. Despite this, direct evidence from high-quality randomized controlled trials specifically investigating sprain treatment is limited. The European Medicines Agency (EMA) acknowledges traditional and some clinical use for musculoskeletal pain but does not specifically endorse its use for sprains. In summary, while there is a plausible mechanism and some supporting data for harpagosides reducing inflammation and pain, the evidence for their efficacy in treating sprains is preliminary and indirect, warranting a moderate-low evidence rating.

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