Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Skullcap (Scutellaria lateriflora) has a long history of traditional use in Western herbal medicine for its calming and relaxing effects. Historically, it has been employed to support the nervous system, particularly for conditions involving nervous tension, anxiety, and insomnia. The herb contains several bioactive compounds, including flavonoids like baicalin, which are believed to contribute to its sedative and anxiolytic properties. While modern research on skullcap's effects on specific neurotransmitters is limited, some animal studies suggest that extracts may modulate gamma-aminobutyric acid (GABA) activity, a primary inhibitory neurotransmitter in the central nervous system. However, robust clinical trials in humans are lacking, and the evidence supporting its direct action on neurotransmitter systems is preliminary at best. Most uses in supplements targeting neurotransmitter support are grounded in traditional applications rather than clear scientific validation. As such, skullcap’s inclusion in formulations for supporting the "Specific Neurotransmitters body system" is primarily justified by traditional use rather than strong scientific evidence.

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