Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oleoylethanolamide (OEA) is an endogenous lipid mediator known to regulate feeding, body weight, and lipid metabolism, primarily through activation of the peroxisome proliferator-activated receptor alpha (PPAR-α). With regard to the "Specific Neurotransmitters" body system, OEA’s most direct scientific connection is its effect on neural pathways that regulate satiety and reward, particularly those involving dopamine and histamine signaling in the brain. Several animal studies have demonstrated that OEA modulates dopamine transmission in the striatum and other reward-related brain areas, influencing behaviors related to food intake and reward.

OEA has also been shown to influence acetylcholine release and affect the activity of the vagus nerve, which connects the gut and brain. However, while these findings indicate that OEA does modulate certain neurotransmitters, the bulk of evidence is preclinical, with limited data from human studies. Therefore, while there is emerging scientific validation that OEA affects neurotransmitter systems, the evidence is presently incomplete and mainly extrapolated from animal models. As such, its use to directly support neurotransmitter function in humans is not fully established, warranting a moderate evidence rating.

In summary, OEA has a scientifically plausible mechanism to influence specific neurotransmitter systems, particularly those involved in appetite regulation and reward, but more robust human research is required to confirm its efficacy and safety for this purpose.

More about Oleoylethanolamide
More about Specific Neurotransmitters

Other ingredients that support Specific Neurotransmitters

Other body systems supported by Oleoylethanolamide

Products containing Oleoylethanolamide