Evidence supporting the use of: D-Aspartic Acid
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-Aspartic Acid (DAA) is an amino acid that has attracted scientific interest primarily for its role in hormone regulation, especially regarding testosterone. Its connection to neurotransmitter support is less direct, but there is some evidence that DAA participates in neurotransmitter systems. DAA functions as a neurotransmitter and neuromodulator in the nervous system, influencing the release of hormones and possibly affecting synaptic plasticity. Some animal and in vitro studies indicate that DAA may modulate the release of neurotransmitters such as dopamine and gamma-aminobutyric acid (GABA) in brain tissue. However, direct evidence of its efficacy in supporting general neurotransmitter health or function in humans is limited and inconsistent. Most human research focuses on its effects on hormone levels rather than direct cognitive or neurological outcomes. Clinical studies examining the impact of DAA on mood, cognition, or neuropsychiatric conditions are sparse. As a result, while there is a scientific rationale for DAA’s involvement in neurotransmitter processes, its supplementation for supporting the "Specific Neurotransmitters" body system lacks robust human evidence. The current scientific support is relatively weak and does not conclusively validate DAA supplementation for this intended purpose.

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