Evidence supporting the use of: Citicoline
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citicoline (also known as CDP-choline) is a compound involved in brain metabolism and the synthesis of the neurotransmitter acetylcholine. Several clinical studies and reviews support its use for supporting neurotransmitter function, especially in the context of cognitive decline, stroke recovery, and certain neurodegenerative disorders. Citicoline acts as a precursor for phosphatidylcholine, an essential component of neuronal membranes, and also increases the availability of acetylcholine, a neurotransmitter critical for memory and learning. Randomized controlled trials have shown that citicoline supplementation can improve cognitive function in patients with vascular cognitive impairment and may aid recovery after ischemic stroke, likely by enhancing neuroplasticity and neurotransmitter levels. However, its effects in healthy individuals or in other neuropsychiatric conditions are less well established, and evidence of benefit is moderate rather than definitive. Major systematic reviews and meta-analyses generally regard citicoline as safe and potentially beneficial, though further research is needed to clarify its efficacy across broader populations. In summary, citicoline is scientifically validated to support the neurotransmitter system, with a moderate evidence base, particularly in clinical populations rather than for general cognitive enhancement.

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