Evidence supporting the use of: 5-Methoxytryptamine
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

5-Methoxytryptamine (5-MT), also known as mexamine, is an indoleamine structurally related to serotonin and melatonin. It is an endogenous compound found in the mammalian brain, and research indicates that it can act as a serotonin receptor agonist, meaning it can bind to and activate certain serotonin receptors. This relationship forms the basis for its use to support the “Specific Neurotransmitters” body system, as serotonin is a key neurotransmitter involved in mood, sleep, and circadian rhythm regulation.

Animal studies have shown that 5-MT can cross the blood-brain barrier and influence serotoninergic signaling, with some evidence indicating it can elevate serotonin levels and display antidepressant-like effects in rodents. There is also preliminary research examining its neuroprotective effects and its influence on sleep patterns, likely via its interaction with serotonin and melatonin pathways.

However, human studies on 5-MT are very limited, and its use as a supplement for supporting neurotransmitter balance or specific neurotransmitter-related body systems is not well established in clinical practice. Most of the available data comes from preclinical research. Therefore, while there is a scientific rationale and experimental support for its action on neurotransmitter systems, the strength of evidence for its use in humans remains weak to moderate at best.

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Other body systems supported by 5-Methoxytryptamine

Serotonin
Specific Neurotransmitters

Products containing 5-Methoxytryptamine